We determine that the PBMC DNA methylation characters of progression of liver disease (7888 CGs) and difference between LC and CHB (4325 CGs) remain significant after correction for HBV markers (Supplementary table 10 and 11) and PBMC cell type (CD4+ T cell, CD8+ T cells, B Cells, natural killer cells, monocytes, granulocytes). This evidence concerns the gene CD4 and laryngotracheoesophageal cleft.