GPT and Decreased liver function: Liver enzymes (ALT and AST) and serum lipid profiles (TC and TG) were markedly increased in T2DM rats compared with those in the control group and were decreased dramatically in HucMDE-treated T2DM rats compared with those in the HDE-treated group (Table 1), indicating that HucMDEs relieved liver dysfunction and improved lipid profiles in T2DM rats.