PTEN and cancer: Also, 39% of the altered positions seen in these genes, including TP53, EGFR, and PTEN, have not been previously seen in the TCGA GBM dataset, but have been observed in other cancers [26, 27] and/or are included in the Memorial Sloan Kettering (MSK) cancer hotspot resource [28] (Additional file 3: Table S2).