APOE and atherosclerosis: Similarly, a study into the role of exosomes in the progression of atherosclerosis employed exosomes derived from oxidized low-density lipoprotein (oxLDL)-stimulated macrophages and revealed that intravenous administration of oxLDL-treated macrophage cell-derived exosomes into male ApoE-deficient atherosclerosis mice significantly deteriorated atherosclerosis in vivo [38].