MAPT and Cognitive impairment: The present study demonstrates that circulatory factors in young blood can downregulate inflammation, reduce Aβ deposition, and decrease tau phosphorylation, which could have contributed to the reversal of cognitive impairment in aged 3×Tg-AD mice; 3×Tg-AD mice are known to become cognitively impaired as early as the age of 3 months [39].