We showed that these QTLs are highly associated with CAD GWAS loci and correlated to lead SNPs in these loci, colocalize with smooth muscle cell transcription factor binding and epigenetic modification, and show allele-specific function in CAD GWAS loci and that these functional mapped variants can serve as response QTLs that link expression of causal CAD genes to epigenetic stimulation. This evidence concerns the gene CAD and coronary artery disorder.