The PI3K/AKT/mTOR pathway has been implicated in the development of various types of cancer regulated by m6A proteins, including METTL3/WTAP in AML [41, 43], METTL3 in RCC/PDAC [78, 107], ALKBH5 in EOC [96], and FTO in melanoma [97] and EC [109]. This evidence concerns the gene METTL3 and melanoma.