PPARG and cancer: Second, considering the potential effect of the modification or interaction between two exposure factors, we further investigated the effect of NSAID intake on the cancer risk and calculated the pooled ORs stratified by the carrying status of the PPARγ rs1801282 polymorphism (CC carriers: OR (95% CI) = 0.743 (0.673–0.820), P < 0.001; CG or GG carriers: OR (95% CI) = 0.811 (0.622–1.056), P = 0.12, shown in Table 6).