To gain insight into the regulation of AQP11, the role of tumor necrosis factor α (TNF-α) and transforming growth factor β1 (TGF-β1), two molecules tightly involved in obesity-associated inflammation and ER stress, was analyzed as plausible regulators of AQP11 in human omental adipocytes. This evidence concerns the gene AQP11 and obesity due to melanocortin 4 receptor deficiency.