LEP and obesity due to melanocortin 4 receptor deficiency: AQP11 protein expression levels in visceral fat were positively correlated with markers of adiposity, such as BMI (r = 0.48, p = 0.004), body fat (r = 0.49, p = 0.004), and leptin (r = 0.42, p = 0.016), and with the acute-phase reactant CRP (r = 0.37, p = 0.041), suggesting an involvement of this superaquaporin in obesity-associated inflammation.