In this study, the HMW PEI-K14 was prepared by cross-linking LMW PEI with a bifunctional peptide K14, and then coupled with CUR through CPLGIAG peptide, and at last self-assembled with p53 to form a co-delivery system CUR-PEI-K14/p53, so as to deliver CUR and p53 simultaneously, and synergistically enhance the sensitivity of ovarian cancer resistant cells to platinum chemotherapy. Here, TP53 is linked to ovarian carcinoma.