When combined (irrespective of MTHFR mutation or IAS phenotype), the mean L-Arg/ADMA ratio was lower in the whole group of our cryptogenic stroke patients than in healthy subjects, although still higher if compared to the L-Arg/ADMA ratio obtained in patients with acute myocardial infarction (Figure S1). The gene discussed is MTHFR; the disease is acute myocardial infarction.