Correspondingly, we found that colonic cancer cells responded to IL-4 and IL-13 stimulation with upregulation of CLDN2, significantly so in case of IL-4, while ACTA2 and TJP1 tended to be rather downregulated, significantly so in case of Caco-2 stimulation with IL-4. The gene discussed is CLDN2; the disease is malignant colon neoplasm.