For instance, a pooled meta-analysis assessing long-term survival of 1861 advanced melanoma patients estimated a 3-year survival rate of 22% for patients receiving anti-CTLA4 ipilimumab [52], which evidently outperformed other chemotherapy such as dacarbazine, where the 3-year survival rates were only around 12% [53]. This evidence concerns the gene CTLA4 and melanoma.