Metformin modulates the following axes: miR-miR-708/CD47 in breast cancer [33], miR-27b/ENPP1 in breast cancer [34], 26a/EZH2 in pancreatic cancer [35], and blocks TGFβ1-induced upregulation of miR-181a and downregulation of miR-96 in breast cancer [36]. This evidence concerns the gene ENPP1 and familial pancreatic carcinoma.