Several miRs have been associated with ADAM10 and c-Met: previous reports showed that miR122 down-regulates ADAM10 expression in breast cancer [21] and hepatocellular carcinoma [22], while miR144 may play a role in down-regulating ADAM10 expression in Alzheimer disease [23]. The gene discussed is ADAM10; the disease is early-onset autosomal dominant Alzheimer disease.