LEP and obesity due to melanocortin 4 receptor deficiency: Furthermore, the interaction between VAT and bone turnover markers observed in this study suggests that future studies investigating the cross-talk between metabolic markers associated with higher VAT such as leptin, adiponectin, insulin resistance, inflammatory cytokines [51] and bone biomarkers and microarchitecture in women with low and high VAT would help to explain the possible links between obesity, poor bone microarchitecture and higher fracture risk.