Furthermore, the interaction between VAT and bone turnover markers observed in this study suggests that future studies investigating the cross-talk between metabolic markers associated with higher VAT such as leptin, adiponectin, insulin resistance, inflammatory cytokines [51] and bone biomarkers and microarchitecture in women with low and high VAT would help to explain the possible links between obesity, poor bone microarchitecture and higher fracture risk. This evidence concerns the gene LEP and Insulin resistance.