The second patient showed the following clinicopathological profile: IIB, T2, N1, M0, invasive ductal carcinoma, histological grade = 2, tumour diameter = 3.0 cm, ER+/PR+ and HER2-, Ki-67 = 15%, and luminal A. The pre-treatment values were YKL-40 = 2.55 ng/mL, leptin = 16.92 ng/mL, adiponectin = 28.49 ng/mL, and TF activity = 8.05 pM. The gene discussed is MKI67; the disease is neoplasm.