The first patient had the following clinicopathological profile: IIA, T2, N0, M0, invasive ductal carcinoma, histological grade = 2, tumour diameter = 2.2 cm, ER+/PR- and HER2-, Ki-67 = 20%, and luminal B HER2 (-). The gene discussed is PGR; the disease is invasive ductal breast carcinoma.