While only some stem cell markers (e.g., SOX2, CD133) and basal cell markers (e.g., KRT5, TP63) are upregulated in post-castrated LTL331 and relapsed NEPC tumor (LTL331R), all of the stem, basal, luminal, and intermediate transient amplifying cell markers were consistently upregulated in LTL331_CR_Cells. The gene discussed is PROM1; the disease is neoplasm.