JAK2 and asthma: For example, in severe asthma, the combined interaction scores for the STAT3, AGO2, COL1A1, CLCN6, and KSR1 genes yielded a higher interaction for the moderate asthma phenotype (Figure 4A), and the JAK2, INSR, ERBB2, NR3C1, and PTK6 genes (Figure 4C) were more interactive for the severe asthma phenotype.