The most enriched pathway in both moderate and severe asthma is the development glucocorticoid receptor signaling pathway, which includes the upregulation of GCR, GCR alpha, and GCR beta (Figure 7A), and this is indicated with a full-red color thermometer labeled with “1” for the genes belonging to the moderate asthma phenotype and “2” for the severe asthma phenotype. This evidence concerns the gene NR3C1 and asthma.