For example, in severe asthma, the combined interaction scores for the STAT3, AGO2, COL1A1, CLCN6, and KSR1 genes yielded a higher interaction for the moderate asthma phenotype (Figure 4A), and the JAK2, INSR, ERBB2, NR3C1, and PTK6 genes (Figure 4C) were more interactive for the severe asthma phenotype. This evidence concerns the gene STAT3 and asthma.