SQSTM1 and amyotrophic lateral sclerosis: This is further supported by studies showing that trehalose, which has beneficial effects in both ALS and SBMA, induces autophagy in a TFEB-dependent manner through upregulation of PPARGC1A as well as well-known autophagy-related genes such as BECN1, LC3, ATG10, ATG12, and SQSTM1/p62 [101].