In turn, these protein aggregates may impair both the UPS and autophagy, while enhancing the UPS and/or autophagy prevents SOD1, TDP-43, and FUS protein aggregation and toxicity within both motor neurons and muscle cells in various ALS models [66,67,68,69,70,71,72,73,74]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.