ICAM1 and gestational diabetes: Since miR-221 and miR-222 are two negative regulators of ICAM-1 [142,143] and are significantly upregulated in fpEC cells derived from GDM in respect to normal pregnancies, Diaz-Perez inferred that these microRNAs may determine the reduced ICAM-1 levels observed in the feto-placental endothelium in GDM [144].