EGFR and colorectal carcinoma: Treatment for stage IV CRC is proposed using various strategies such as (i) the combination of capecitabine and oxaliplatin [61], (ii) capecitabine, with or without a targeted drug (NCT00642603) [62,63], (iii) cetuximab (epidermal growth factor receptor inhibitor) [64] and (iv) regorafenib (multi-target kinase inhibitor) [65] or bevacizumab (Avastin®) [26,27,66].