CACNA1S and obesity due to melanocortin 4 receptor deficiency: The investigators then focused on the skeletal muscle cells of rimonabant-treated mice, and found high voltage-activated Ca2+ channels (HVACCs), specifically, Cav1.1 was downregulated in HFD mice, and rimonabant increased Cav1.1 expression in skeletal muscle cells, possibly acting as one of the obesity protective effects of the drug [49].