Defects in any of these three genes, melanophilin (MLPH), myosin Va (MYO5A), and Rab27a (RAB27A), have been linked with several dilute phenotypes and the autosomal recessive Griscelli syndromes in humans (OMIM #214450, 607624, 609227) [4,5]. The gene discussed is MYO5A; the disease is Griscelli syndrome.