These conditions included already known CFTR-RDs, conditions where a higher prevalence of CFTR variants has already been reported, such as allergic bronchopulmonary aspergillosis, asthma, primary sclerosing cholangitis [8] or pancreatic cancer [78] and others that were not previously described associated with CFTR dysfunction, such as cirrhosis or intestina atresia [9]. The gene discussed is CFTR; the disease is sclerosing cholangitis.