CFTR and cystic fibrosis: Complex alleles increase the complexity of CFTR variant classification, as illustrated for the c.445G>A (G149R) CF-causing variant and the c.1327G>T (D443Y) CFTR-RD-causing variant, each of them being described in cis with an already frequent complex allele c.[1727G>C;2002C>T] (G576A;R668C) [51].