Other clinical entities related to CFTR variants have been described since the early 90s, with a continuum of CFTR dysfunction, from CFTR-related disorders (CFTR-RD), which are defined by evidence of CFTR dysfunction but do not meet the criteria for a CF diagnosis [7], to a number of conditions associated with a higher proportion of CF carriers compared to the general population, such as asthma or bronchopulmonary allergic aspergillosis [8]. This evidence concerns the gene CFTR and asthma.