These conditions included already known CFTR-RDs, conditions where a higher prevalence of CFTR variants has already been reported, such as allergic bronchopulmonary aspergillosis, asthma, primary sclerosing cholangitis [8] or pancreatic cancer [78] and others that were not previously described associated with CFTR dysfunction, such as cirrhosis or intestina atresia [9]. This evidence concerns the gene CFTR and familial pancreatic carcinoma.