In particular, (i) NB4 is a human acute promyelocytic leukemia-derived cell line characterized by the t(15;17) PML-RARA fusion gene, (ii) HL60 are cells derived from a human acute myeloid leukemia classified as FAB M2 and featured by MYC oncogene amplification, and (iii) K562 cells are obtained from chronic myeloid leukemia (CML) in blast crisis and the K562 cells carry the t(9;22) BCR-ABL1 e14-a2 (b3-a2) fusion gene. Here, RARA is linked to acute myeloid leukemia.