SPOP and posterior cortical atrophy: Results obtained in primary prostate cells from conditional SPOP-F133V transgenic mice, as well as in human normal prostate and PCa cell lines ectopically expressing SPOP-WT or SPOP-F133V, suggest that SPOP participates in the DNA damage response (DDR) and that SPOP mutation impairs homologous recombination (HR) [7], which is the main repair pathway of DNA double strand breaks (DSB).