A number of highly relevant substrates have been reported as deregulated by mutant SPOP in PCa cells, including the androgen receptor (AR) and its co-activators steroid-receptor co-activator-3 (SRC-3) and tripartite motif containing 24 (TRIM24) [8,9,10,11,12]. The gene discussed is TRIM24; the disease is posterior cortical atrophy.