SPOP and posterior cortical atrophy: Results from the study, which represents the first attempt to directly compare the radiosensitizing effect of SPOP deregulation accomplished through different approaches, could contribute to tailoring therapy of individual PCa patients by delivering a genomic-adjusted radiation dose, instead of a uniform dose (i.e., one-size-fits-all) and to highlight the possibility of developing novel strategies of radiosensitization based on SPOP targeting.