Contrary to the total lymphocyte and the CD4+ and CD8+ T-cell subset reduction, patients with COVID-19 exhibit increased CD4+ T-cell relative frequency of the C-C motif chemokine receptor 6 (CCR6) positive T helper (Th) 17 effector phenotype [9], thus exhibiting over-activation of the immune system towards inflammation. This evidence concerns the gene CCR6 and COVID-19.