INS and Insulin resistance: One additional factor future studies might consider is the exploration of possible associations of altered telomere dynamics with glucose tolerance and insulin sensitivity, as three months HFD induces insulin resistance in C57BL/6J young mice (Liu et al., 2015) and we (Reynolds et al., 2019) and others (Oh et al., 2016) have documented that changes might begin at 16 months, but are more pronounced at 20 months of age.