However, significant hyperglycemia in the absence of insulin release during low‐frequency vagus nerve stimulation has been reportedly previously (Meyers et al., 2016), and is thought to be due to afferent‐dependent suppression of insulin release that is centrally mediated by the indirect activation of sympathetic splanchnic nerve, known to cause suppression of insulin release (Andersson et al., 1982; Dunning, Ahren, Veith, & Taborsky, 1988; Holst, Schwartz, Knuhtsen, Jensen, & Nielsen, 1986; Meyers et al., 2016). This evidence concerns the gene INS and Hyperglycemia.