TP53 and lung adenocarcinoma: A strong inverse correlation between S100A4 and p53 has been shown by immunohistochemistry in lung adenocarcinoma, suggesting that the level of S100A4 is higher in wild‐type p53 tumors.[36] A trend toward inverse correlation between S100A4 and p53 was also shown in a breast cancer cohort, where a higher level of S100A4 was found to be a negative prognostic factor.[37] Thus, the importance of this complex lies in its potential role in the survival of cancer cells.[32, 38, 39] Despite all these, only limited structural information is available.