Although guidelines’ recommendation against routine cancer screening in older adults with limited life expectancy does not distinguish between different screening modalities,9,10,11,12,13,14,15 we found in theme 3 that clinicians often switched to less invasive screening options or using physical exam for screening, rather than stopping screening altogether, even when clinicians considered the standard screening tests (mammogram, prostate-specific antigen, colonoscopy) to be no longer appropriate. The gene discussed is KLK3; the disease is cancer.