Indeed, we and others have previously reported that GFP-LC3 can be used to monitor the autophagic status as well as disease progression in a GFP-LC3-expressing animal model of amyotrophic lateral sclerosis (ALS); i.e., human mutant SOD1-expressing transgenic mice [10, 11]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.