The most enriched gene sets in the three MYO5B mutants were the following four up-regulated: “Hallmark Myc targets v1”, “KEGG Base excision repair”, “KEGG Basal transcription factors”, “Hallmark E2F targets”, and four down-regulated: “Hallmark TNFA Signaling via NFKB”, “Hallmark Inflammatory response”, “KEGG ECM Receptor interaction”, “KEGG Arrhythmogenic right ventricular cardiomyopathy ARVC” (S7 Table). This evidence concerns the gene NFKB1 and arrhythmogenic right ventricular cardiomyopathy.