Both had lower mean total cholesterol (-0.78 SD in e2e2, p=1.56×10-314 versus -0.33 SD in e2e3, p<1×10-323), LDL cholesterol (-1.12 SD in e2e2, p<1×10-323 versus -0.43 SD in e2e3, p<1×10-323), lipoprotein A (-0.40 SD in e2e2, p=4.58×10-62 versus -0.10 SD in e2e3, p=1.41×10-61), and apolipoprotein B (-1.99 SD in e2e2, p<1×10-323 versus -0.56 SD in e2e3, p<1×10-323), plus higher apolipoprotein A1 (0.13 SD in e2e2, p=8.37×10-11 versus 0.11 SD in e2e3, p=1.51×10-104), all associated with lower risks of CAD. The gene discussed is APOB; the disease is coronary artery disorder.