EGFR and lung cancer: Analyses of EGFR mutation frequencies have showed varying rates in LATAM countries (approximately 15% in Argentina; 20%-25% in Brazil; 25%-35% in Mexico, Costa Rica, and Colombia; and 55% in Peru).18-20 Interestingly, the population in Peru is mostly of Native American descent (with some influence of the migrations of East Asia; ie, China and Japan), whereas the Brazilian, Mexican, Costa Rican, and Colombian populations are mixed.18 These observations suggest that somatic mutation frequency in EGFR in lung cancer could be associated with genetic ancestry.