GDF9 and premature menopause: Among the SNPs in the GDF9 gene that have been associated with infertility and POF (Kovanci et al., 2007), the most notable are C398-9G (Dixit et al., 2005), C447T (Dixit et al., 2005, Serdyńska-Szuster et al., 2016), G546A (Serdyńska-Szuster et al., 2016; Wang et al., 2010), and G646A (Dixit et al., 2005).