In cohort #2 (Fig 1B), NfL levels were also significantly higher in ataxic SCA3 subjects (85.5 pg/ml [70.2–100.2]) than in controls (19.4 pg/ml [15.1–25.4]; U = 16, z = 6.98, P < 0.001, r = 0.81). Here, NEFL is linked to Spinocerebellar ataxia type 3.