A FA patient mutation in FANCI, R1285Q, which reduces ubiquitination of the ID2 complex 20, 21, has been suggested to reduce both FANCI and ID2 DNA binding, as well as FANCI interaction with FANCD2; however, the magnitude of reduction in DNA binding contrasts between the studies 20, 21, 22. The gene discussed is FANCD2; the disease is Friedreich ataxia.