Further evidence that some of the presented proteomic alterations of rodent microglia may be relevant for human disease is given by the detection of up-regulated early/middle microglial MARPs, including CD68, TREM2 and ITGAX in microglia surrounding amyloid plaques in postmortem AD brains (Hopperton et al., 2018). Here, TREM2 is linked to Alzheimer disease.