Up-regulated are the early (APOE, ACACA, and SOAT1) middle (FABP3, FABP5, NCEH1, APOD, AACS, ACOX3, HACD2) and advanced MARPs (ACOT11, ACSBG1, ECHS1, ELOVL1, and FASN) and down-regulated are several middle and advanced MARPs (NAAA, FAM213B, HPGD, HPGDS, and PRKAB1), linking microglial lipid dyshomeostasis and AD pathology. The gene discussed is PRXL2B; the disease is Alzheimer disease.