Strikingly, the human orthologs of the mouse FMRP localization targets were significantly less neurite-localized in FXS neurons than in unaffected neurons, indicating that the functional localization targets of FMRP were broadly conserved across species (mouse and human) and experimental systems (neuronal cell line and iPS-derived neurons) (Figure 3C). Here, FMR1 is linked to fragile X syndrome.