FOXC2 and lymphedema: In contrast, mutations in FOXC2 have been dominantly associated with lymphedema-distichiasis syndrome characterized by failure of lymph drainage in limbs, venous valve failure, and the growth of an extra set of eyelashes (Tümer and Bach-Holm, 2009; Micheal et al., 2016; Aldinger et al., 2009; French et al., 2014; Fang et al., 2000; Traboulsi et al., 2002; Tavian et al., 2016; Mellor et al., 2007).