PTGS2 and neoplasm: For example, the noncoding RNA activated by DNA damage (lncRNA NORAD, also known as LINC00657) functioned as a tumor suppressor gene in lung cancer [41], but it was up-regulated in CCI rats and contributed to neuroinflammation through inducing expression of COX2, TNF-α and IL-1β [42], which is quite similar to lncRNA DILC.