GNRH1 and polycystic ovary syndrome: Women with PCOS often show a neuroendocrine disturbance, with increased LH pulse secretion, with little effect on FSH secretion, presumably reflecting a similar perturbation in GnRH neuronal activity (Santen and Bardin, 1973; Rebar et al., 1976; Marshall et al., 2001; Moore and Campbell, 2017).