That NK3Ra abolished the positive correlation between serum oestradiol and LH response to kisspeptin in women PCOS suggests an additional level of interaction between kisspeptin and NKB; similarly, in healthy women, under high exogenous oestrogen exposure, NK3Ra shortened the LH response to kisspeptin-10 and disrupted the relationship between the kisspeptin effect and oestradiol concentrations (Skorupskaite et al., 2016). Here, TAC3 is linked to polycystic ovary syndrome.