In women with PCOS, NK3R antagonism had no detected effect on oestradiol concentrations, which is in contrast to healthy women administered this drug during the follicular phase of the menstrual cycle, where reduced oestradiol secretion was thought to have increased (or prevented a decrease) in FSH release (Skorupskaite et al., 2018a). Here, TACR3 is linked to polycystic ovary syndrome.