Whilst these data show largely similar effects to those seen in normal women, the differences in both the effects of NK3R antagonism and response to kisspeptin-10 may be attributable to the precise level of sex-steroid feedback, and do not indicate major differences in the neuroendocrine regulation of LH secretion in PCOS at the level of the KNDy neurone. Here, TACR3 is linked to polycystic ovary syndrome.