That NK3Ra abolished the positive correlation between serum oestradiol and LH response to kisspeptin in women PCOS suggests an additional level of interaction between kisspeptin and NKB; similarly, in healthy women, under high exogenous oestrogen exposure, NK3Ra shortened the LH response to kisspeptin-10 and disrupted the relationship between the kisspeptin effect and oestradiol concentrations (Skorupskaite et al., 2016). The gene discussed is KISS1; the disease is polycystic ovary syndrome.