TNF and major depressive disorder: To determine whether the prolonged allodynia, spontaneous pain, and depression-like behavior observed in T cell-deficient mice result from more pronounced or prolonged (neuro)inflammation, we measured mRNA expression of the prototypical pro-inflammatory cytokines Il1b and Tnf at the site of CFA injection (paw), and in the CNS (ipsilateral lumbar spinal cord (SC) and contralateral prefrontal cortex (PFC)).