Moreover, studies by Pandurangan et al. showed that luteolin – a major flavonoid found in chamomile – decreased the expressions of iNOS and COX-2 in AOM-induced CRC in mice [69] and induced growth arrest in colon cancer cells via the Wnt/β-catenin/GSK-3β signaling [70]. This evidence concerns the gene PTGS2 and malignant colon neoplasm.