The dataset represents the raw data (supplementary Table), frequencies of alleles, genotypes (Table 1) and haplotypes (Table 2) for five SNPs (rs1063192, rs7865618, rs2157719, rs944800 and rs4977756) of the CDKN2B-AS gene in Russian patients with POAG. This evidence concerns the gene CDKN2B and open-angle glaucoma.