SOD1 and type 2 diabetes mellitus: Due to the important effects of the probiotic and prebiotic supplementation on hyperglycemia-induced oxidative stress and its protective impact on the production of proinflammatory cytokines, this paper investigated the effects of separate and concurrent supplementation of Lactobacillus plantarum 1085 (ATCC 8014) and inulin on T2DM-induced cardiac apoptosis by evaluating the cardiac antioxidant parameters including MDA, total antioxidant capacity (TAC), GPx, and SOD activity and the expression of the cardiac obesity receptor (Ob-R) as well as cardiac apoptotic markers.