Moreover, compared to mice fed a HF+HS diet, mice fed a diet of HF+HS+S (5% SBP) had lower plasma glucose, insulin, HOMA-IR, body weight, food intake, cholesterol, triglyceride, monocyte adhesion, TNFα, PAI-1, MCP-1, ICAM-1, and uPAR. The gene discussed is PLAUR; the disease is hydrops fetalis.