As shown in Figure 5, the top ten significant pathways were as follows: systemic lupus erythematosus, spliceosomes, amoebiasis, African trypanosomiasis, porphyrin and chlorophyll metabolism, Amyotrophic lateral sclerosis (ALS), Malaria, Renin secretion, Taurine and hypotaurine metabolism, and Tuberculosis. This evidence concerns the gene REN and systemic lupus erythematosus.